猕猴皮层空间转录组的细胞类型注释结果数据集

大脑皮层在感觉、认知、学习和记忆等功能中发挥着重要的作用，主要依赖于其复杂的神经元和非神经元组成，且不同的脑区所执行的功能不同。选择与人亲缘关系最近的模式生物猕猴作为研究对象，通过单细胞转录组技术和空间转录组技术获取不同细胞类型在脑区的具体位置，可以更好地理解脑区功能和细胞类型的联系，提供更多关于大脑神经网络运作的规律。

This dataset focuses on the cerebral cortex, which plays a critical role in core brain functions such as sensation, cognition, learning and memory, and largely relies on its complex cellular makeup comprising both neurons and non-neuronal cells. Distinct brain regions have specialized functional roles. The rhesus macaque, the closest model organism to humans in evolutionary kinship, was selected as the research subject. By employing single-cell transcriptomic and spatial transcriptomic technologies to map the precise spatial distributions of distinct cell types across various brain regions, this dataset enables better elucidation of the links between brain region functions and cell types, and provides enhanced insights into the operational principles of brain neural networks.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于猕猴大脑皮层的细胞类型空间分布研究，利用单细胞转录组和空间转录组技术获取了不同细胞类型在脑区的具体位置信息，旨在深入理解脑区功能与细胞连接。数据集包含大量实验文件（174个文件，总容量564.16 GB），提供了详细的细胞类型注释结果，适用于神经科学和脑网络研究。