Pathways putatively regulated by curcumin-altered miRNAs as found by over-representation analysis.

Listed are pathways being putatively regulated by miRNAs of B78H1 melanoma which are altered by curcumin diet, as found by over-representation analysis with the online analysis-tool GeneTrail. As test sets we used the predicted targets of differentially regulated miRNAs and as reference set the putative targets of all murine miRNAs printed on the microarray. GeneTrail exhibited a search in disease-relevant cellular pathways as found in the Kyoto Encyclopedia of Genes and Genomes (KEGG) for enrichment of putative targets. MiRNAs up-regulated by curcumin diet (upper part of table) were separately tested from down-regulated miRNAs (lower part of table). The expected number of target genes, modulated in a pathway, is shown as well as the observed ones, including the according P-value and x-fold enrichment of targets.