Single-marker transmission disequilibrium tests in the detection sample (424 obesity trios), the confirmation sample (363 obesity trios) and in the joint sample (787 obesity trios).

abase pair position on chromosome 18 according to http://www.ncbi.nlm.nih.gov (hg18);bobesity effect allele frequency;cconfidence interval;dp-values were calculated using PLINKs′ adaptive permutation procedure with 106 permutations.Displayed are the SNPs included in the three best haplotypes (Table 1) for the explored genomic region surrounding the melanocortin 4 receptor gene (MC4R, location: chromosome 18: 55,879,013–56,243,921 bps). The obesity-predisposing allele (obesity effect allele) within each sample is highlighted in bold.