RNA Microarray data from embryonic mouse brains wt vs foxf2 mutant

Brain of the foxf2 mutant mouse embryo shows microvascular aneurysm, underdeveloped blood brain barrier and also significant defects in the tissue integrity. Foxf2 expresses in the pericytes of the brain and seem to play an important role in proper development of the BBB. Brains of E18.5 wt and foxf2 mutant mouse embryos dissected and RNA extracted from the brains using Sigma mammalian total RNA extraction kit. The RNA then been sent to the core facility for hybridization.Foxf2突变小鼠胚胎的脑组织可见微血管动脉瘤、血脑屏障（blood brain barrier, BBB）发育不全，同时存在显著的组织完整性缺陷。Foxf2在脑组织周细胞中表达，似乎在血脑屏障的正常发育中发挥重要作用。本研究解剖获取了胚胎发育第18.5天（E18.5）的野生型（wild type, wt）与foxf2突变小鼠胚胎的脑组织，采用Sigma公司的哺乳动物总RNA提取试剂盒提取脑组织总RNA，随后将总RNA送至实验核心平台进行杂交实验。