Th1 cytokine responses in CD4+ and CD8+ T cells from GS-4774 vs. Ovax-immunized C57BL/6 mice.
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Intracellular cytokine staining was used to assess the production of IFNγ, IL2, and TNFα by CD8+ T cells in the presence of peptide HBs190–197 (VWLSVIWM; top), and the production of IFNα in CD4+ T cells in the presence of peptide HBcAg 120–140 VSFGVWIRTPPAYRPPNAPIL (bottom). P values: in parentheses. n.t., not tested. Ovax: control Tarmogen expressing chicken ovalbumin. Splenocytes from 7 vaccinated mice per group were pooled for the analysis.
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2015-12-02
