BACE-1 in complex with HEA-macrocyclic inhibitor, MV078512
收藏Protein Data Bank Japan2024-10-16 更新2026-03-21 收录
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BACE-1 in complex with HEA-macrocyclic inhibitor, MV078512 Descriptor: (4S,8E,11R)-4-[(1R)-1-hydroxy-2-{[3-(propan-2-yl)benzyl]amino}ethyl]-16-methyl-11-phenyl-6-oxa-3,12-diazabicyclo[12.3.1]octadeca-1(18),8,14,16-tetraene-2,13-dione, Beta-secretase 1 Authors: Lindberg, J, Borkakoti, N, Derbyshire, D. Deposit date: 2012-02-13 Release date: 2012-07-11 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes. Bioorg.Med.Chem., 20, 2012
创建时间：
2012-02-13
