Longitudinal changes on continuous outcome measures: depressive symptoms, anxiety symptoms, caregiver burden and health related quality of life.

CES-D: Center for Epidemiologic Studies Depression Scale; HADS-A: Hospital Anxiety and Depression Scales; CRA: Caregiver reaction assessment scale; SF-12: Short Form 12 item version; CI: Confidence interval; R*T: Randomization-by-time interaction. *The coefficient represents the estimated difference of the scores between the intervention and usual care group over 12 months. Scores were adjusted for HADS-A baseline differences and estimated with multilevel analysis.