Functional association between the Microprocessor complex and the Spliceosome in the processing of Splice site Overlapping microRNAs

In SO-miRNAs, a group of pre-miRNAs that overlap with intron-exon junction, the spliceosome and microprocessor complex compete on the nascent transcript regulating the production of two alternative gene products from a shared transcript. In this study, we examined the processing of human SO-miRNAs on a global basis and demonstrated that SF3B1-mediated splicing inhibition preferentially increases the production of these miRNAs.