Longitudinal exercise transcriptomics in the skeletal muscle and liver of two widely used mouse strains

Exercise accelerates the metabolic demands of the skeletal muscle, necessitating a robust response from the liver. However, while substantial data has elucidated the molecular responses to acute exercise and training in the skeletal muscle, comparatively little is known about corresponding molecular events in the liver. Here, we address this gap by performing a longitudinal transcriptomic analysis of mouse skeletal muscle and liver in response to a single bout of acute exercise. Here, we fill this gap by performing longitudinal transcriptomic analysis of mouse skeletal muscle and liver in response to a single bout of acute exercise. We overlaid time-series datasets from BALB/c and C57BL/6J, two most widely used laboratory mouse strains, to identify the common and credible exercise-responsive genes, many of which have no previously defined roles in exercise adaption.