ETAP FY25 TTT NFDHA Sample Metadata

The EPA Transcriptomic Assessment Product (ETAP) is a human health assessment that utilizes a standardized short-term in vivo study design and data analysis procedures to develop transcriptomic-based reference values for data poor chemicals. The reference value represents the daily dose of the chemical that would likely be without appreciable risk to human health over a lifetime. This dataset corresponds to the transcriptomic studies on nonafluoro-3,6-dioxaheptanoic acid (DTXSID30382063, CASRN 151772-58-6) and 1,3,5-trimethyl-1,3,5-triazinane-2-thione (CASRN 59887-80-8, DTXSID 60873116). Male and female Sprague Dawley rats were exposed via oral gavage for 5 days with nine doses (0.01, 0.1, 0.3, 1.0, 3.0, 10.0, 30.0, 100.0, 300.0 mg/kgday) of nonafluoro-3,6-dioxaheptanoic acid and a vehicle control (corn oil) and with eight doses (0.01, 0.1, 0.33, 1.0, 3.3, 10.0, 33.3, 100.0 mg/kg-day) of 1,3,5-trimethyl-1,3,5-triazinane-2-thione and a vehicle control (Propylene Glycol). At the end of the exposure period, gene expression changes were measured in the liver, kidney, spleen, thyroid, heart, adrenal gland, ovary (female), testes (male), thymus, uterus (female), brain, and lung. Data is hosted in s3://dmap-stage-ccte-httr/BioSpyder/68HERC20D0028/68HERC24F0534 (internal to EPA). The data will be hosted in GEO public functional genomics data repository (https://www.ncbi.nlm.nih.gov/geo/) when it is made public. This dataset does not involve human subjects research or contain protected health information (PHI), or personally identifiable information (PII). More information about ETAP is available at: https://www.epa.gov/etap