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STAT3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis

ChEBI2010-10-20 更新2026-07-21 收录

硬化性胆管炎

纤维化机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-18759 数据链接链接失效反馈

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STAT3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis

应用场景：

创建时间：

2010-10-20

纤维化机制

受体信号通路

Liver fibrosis is a reversible wound-healing response to liver injury and hepatic stellate cells (HSCs) are central cellular players that mediate hepatic fibrogenesis. However, the molecular mechanism

NIAID Data Ecosystem120

miR-452-5p mediates SCN5A dependent fibrosis via TGF-beta/SMAD4 axis

纤维化机制

TGF-β信号通路

SCN5A coding for sodium channels in the heart and its reduced activity implicated various biological processes including fibrogenesis. However, the mechanistic interplay between loss of SCN5A activit

NIAID Data Ecosystem30

Table6_Network Pharmacological Analysis and Experimental Validation of the Mechanisms of Action of Si-Ni-San Against Liver Fibrosis.XLSX

纤维化机制

中药网络药理学

Background: Si-Ni-San (SNS), a commonly used traditional Chinese medicine (TCM) formula, has potency against liver diseases, such as hepatitis and non-alcoholic fatty liver disease (NAFLD). However, t

NIAID Data Ecosystem30

Structure of NNQQNY as an insert in T7 endonuclease I

蛋白质结构解析

纤维化机制

Structure of NNQQNY as an insert in T7 endonuclease I Descriptor: Endonuclease I Authors: Guo, Z, Eisenberg, D. Deposit date: 2008-02-19 Release date: 2008-07-22 Last modified: 2023-08-30 Method: X-RA

Protein Data Bank Japan2023-08-30 更新90

RNA-seq of fibrotic liver tissues from CCL4-induced mice. Mus musculus strain:C57/BL6

纤维化机制

RNA测序分析

To investigated the role of CD73 in liver fibrosis, RNA-sequencing of fibrotic liver tissues from CCL4-induced mice were performed. Three groups (three mice for each group) were included in this study

NIAID Data Ecosystem30

STAT3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis

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