RNA Sequencing of postnatal mouse Math1-Cre; Sufu flox/- cerebellum

Transcriptional profiling to identify genes differentially regulated by Sufu during cerebellum development. Sufu was specifically deleted from the granule neuron compartment using Math1-driven Cre recombinase. Whole cerebella were collected from 4 Math1-Cre; Sufu (flox/-) mice and 4 control littermates (Sufu flox/+) at 2 days postnatal, followed by RNA extraction and next generation RNA sequencing本数据集通过转录谱分析（Transcriptional profiling），旨在鉴定小脑发育过程中受Sufu差异调控的基因。实验利用Math1驱动的Cre重组酶（Cre recombinase），在颗粒神经元区室中特异性敲除Sufu。研究收集了出生后2天的4只Math1-Cre; Sufu（flox/-）小鼠与4只同窝对照小鼠（Sufu flox/+）的全小脑，随后开展RNA提取与下一代RNA测序。