Synthesis of Chiral α‑Trifluoro­methyl­amines with 2,2,2-Trifluoro­ethylamine as a “Building Block”

The β-isocupreidine, a cinchonine derived alkaloid, catalyzed asymmetric SN2′–SN2′ reaction between N-2,2,2-trifluoroethylisatin ketimines and MBH type carbonates was realized in a simple and efficient way. A series of chiral α-trifluoromethylamines were prepared with excellent yields and stereoselectivities. A subsequent and easy process of deprotection gave γ-trifluoromethyl-α-methylene­lactam in a stereoselective manner.