Proteomic Profiling of the Prefrontal Cortex Reveals Dysregulated Mitochondria-Metabolism-Synapse Axis in a Chronic Stress-Induced Mouse Model of Depression

This project aims to systematically analyze the differences in protein expression in the prefrontal cortex (Prefrontal Cortex, PFC) of Chronic Social Defeat Stress (CSDS) model mice and normal control group mice using quantitative proteomics technology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS). It will screen key differentially expressed proteins (Differentially Expressed Proteins, DEPs) associated with CSDS-induced depressive-like behaviors, explore the signaling pathways and molecular mechanisms they participate in, and provide solid proteomic data support and theoretical basis for research on the pathogenesis of depression, screening of potential diagnostic markers, and development of targeted therapeutic drugs.