Discovery of Novel Serum Peptide Biomarkers for CCA Recurrence Through MALDI-TOF and LC-MSMS Peptidome Analysis

Cholangiocarcinoma (CCA) is an aggressive cancer originating from bile duct epithelial cells, with a high rate of recurrence following surgical resection. Recurrence is categorized as early linked to aggressive tumor biology than late recurrence. This study aimed to identify novel peptide mass fingerprints (PMFs) and potential biomarker penel in the serum of CCA patients with early and late recurrence using mass spectrometry.