Epigenetic inflexibility of exhausted T cells limits durability of reinvigoration by PD-1 blockade
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE86797
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Upon PD-1 pathway blockade,the epigenetic landscape of exhausted cells was only minimally remodeled consistent with lineage commitment and re-exhaustion of these cells over time. Epigenetic profiling of Exhausted T cells & examinaton of epigenetic changes associated with PD-pathway blockade by ATAC-seq using the mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV)
创建时间：
2025-05-30
