Isolation and characterization of a MAGE gene family in the Xp21.3 region.
收藏PubMed Central1995-05-23 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC41832/
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资源简介：
A human gene with strong homology to the MAGE gene family located in Xq27-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval. MAGE-Xp is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested. However, the gene and predicted protein structure are conserved, suggesting a similar function. MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1995-05-23
