Vibriocidal antibody titers and proportion of ≥ 4 fold rise from baseline GMT in adults.

bGeometric mean-fold rise from baseline to 14 days after first dose or from baseline to 14 days after second dosec # with ≥4 fold rise in titers from baseline to 14 days after first dose or from baseline to 14 days after second dosed 95% confidence intervals using Wilson Score methode Primary endpoint. Difference in seroconversion rates after second dose were calculated by subtracting 14 day interval from 28 day interval. The 28 days interval group is non-inferior to the 14 day interval group as the lower limit of the proportion difference is greater than pre-defined cut-off (-20%)Vibriocidal antibody titers and proportion of ≥ 4 fold rise from baseline GMT in adults.