Metabolic measures in adolescents with obesity

Project description: The study is to measure energy
expenditure in obese youth. Clinical, laboratory and indirect calorimetry data
from youth with overweight and obesity enrolled in metabolic studies at the
university of Colorado and Vanderbilt University are included. Data are
from individuals between age 12 years and 21 years, BMI equal to or greater
than 85th percentile or BMIz equal to or greater than 1.04 for age and sex,
pubertal stage as Tanner 1 - Tanner 5, and no known genetic, structural, or
injurious cause of obesity. Youth with PCOS or T2D were included. CHCO included
data from 7 unique studies, including one retrospective report, and 7
prospective trials, including NCT030411329, NCT03717935, NCT03919929,
NCT02157974, NCT04128995; two studies do not have NCT identification. VUMC
included NCT02411461. Study Approval: The study protocols were approved
by the respective institutional review boards. Informed consent was obtained
from all participants 18 years or older and parental consent and participant
assent from all participants <18 years old. Physical characteristics and
body composition Body weight and stature were measured to the nearest
kilogram and centimeter. BMI was calculated and BMI z-score (BMIz) was
determined based on CDC age and sex-based equations. Waist circumference was
measured at the narrowest circumference in cm. Dual-energy X-ray absorptiometry
(DXA) was used to measure lean mass (LM), fat mass (FM), and fat free mass
(FFM) – all listed in kg. DXA equipment included Hologic (Discovery, Delphi,
and Horizon) at University of Colorado and Lunar Prodigy, GE Medical Systems,
Madison, WI at VUMC. Resting energy expenditure Morning fasted indirect
calorimetry was collected after a period of at least 30 minutes of supine
resting in all participants. Equipment was V Max Encore Carefusion Corp, San
Diego CA at University of Colorado, Parvomedics at VUMC. Measured resting
energy expenditure is listed in kcal/day, respiratory quotient Laboratory
measures: Free fatty acids were measured with enzymatic assay by WaKo Chemicals
USA, and listed in UEQ/L. Fasting glucose is listed in mg/dL and fasting
insulin in mIU/L.

<br><br><br><br><br>