Percent changes (Δ-values) in transcript levels, protein levels and proteolytic activity of Separase after IM treatment when compared to the corresponding untreated cells.1, 2

1Δ-values were calculated from significant data sets diagramed in Figures 2 and 4.2for representative corresponding immunostained Western blots see Figure 5 panels B and C.Abbreviations: RFU, relative fluorescence units; d, days; h, hours; IM, imatinib; +, increase; −, decrease; U937/c6-On, U937p210BCR-ABL/c6 cells with switched on transgene promoter.