Expression data from human lung cancer cell line NCI-H292

CT45 family is abnormally overexpressed in various types of cancer. However, the molecular mechanisms of the oncogenic CT45 to trigger carcinogenesis and tumor malignant progression are largely enigmatic. We previously reported that CT45A1 functions as a proto-oncogene to promote the transcription in the human breast cancer cells, thereby escalating tumorigenesis and cancer metastasis, However, the mechanism of CT45A1-mediated concurrent overexpression of the multiple oncogenic genes in cancer is unclear. We used microarrays to study the role and mechanism of CT45A1 in gene transcriptional regulation in human lung cancer. Three replicates of NCI-H292_CT45A1-overexpression VS three replicates of NCI-H292_CT45A1-negative