aAcidic and basic amino acids have side chains that are ionized at pH 7.4. All natural amino acids are included except cysteine (C), proline (P), glycine (G), tryptophan (W) bIonized at neutral pH cTh
Additional file 5: Table S4. Amino acid pattern of length 4. Given is the sequence pool 1 (column 1) and sequence pool 2 (column 2), the separation capacity between pools based on hydrophobicity (colu
In spite of its relevant biological role, no general consensus exists on the quantitative characterization of amino acid’s hydropathy. In particular, many hydrophobicity scales exist, often producing
That amino acid properties are responsible for the way protein molecules evolve is natural and is also reasonably well supported both by the structure of the genetic code and, to a large extent, by th