P‑Chirogenic Diphosphazanes with Axially Chiral Substituents and Their Use in Rh-Catalyzed Asymmetric Hydrogenation
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https://figshare.com/articles/dataset/P_Chirogenic_Diphosphazanes_with_Axially_Chiral_Substituents_and_Their_Use_in_Rh-Catalyzed_Asymmetric_Hydrogenation/12994548
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资源简介：
A convenient
synthesis of enantiopure P-chirogenic diphosphazanes
incorporating bulky bisphenol and 1,1′-bi-2-naphthol-derived
substituents via the functionalization of a readily accessible enantiopure
lithium phosphinoamide with chlorophosphoridites was developed. Since
the product requires no subsequent deprotection, the protocol provides
an easy, convenient synthesis of P-chirogenic ligands on the gram
scale. The ligands were applied in the Rh-catalyzed asymmetric hydrogenation
of benchmark substrates furnishing enantiomeric excess values up to
96%.
创建时间：
2020-09-14
