Chromosomal clusters.

Legend: Chromosomal regions bearing non-random methylation changes in the genome of Group 2 (cytokine stimulated) cells (left panel) and in Group 4 (LV infected) cells (right panel) compared to the genome of control Group 1 (unstimulated) cells are indicated. Chromosomal number, the nucleotide position of the start and the end of the region of interest, the number of changes/number of analysed genes in the region and the adjusted p-value are indicated. The non-random accumulation of the changes on the chromosome 6 is highly significant. Although in the other chromosomal regions the deviation from the random pattern is at the limit of statistical significance, it is important to note that in LV infected cells the changes occur in the same regions at always higher proportion.