Transciptomic analysis of cachectic muscles from metastatic allograft models

RNA sequencing analysis of muscles comparing normal muscles with cachectic muscles isolated from mice bearing distant metastasis from C26m2 and 4T1 murine colon and breast cancer cell lines, collected at the onset of weight loss five weeks after tumor cell injection in these mice. Transcriptomic analysis of muscles performed by RNA sequencing (RNA seq) isolated from mice bearing metastatic colon cancer cell line, C26m2 or metastatic breast cancer cell line, 4T1 and their respective age-matched healthy controls. Mice bearing distant metastases were compared using the resection-and-relapse approach after 5 weeks post-tumor cell injection.