The effect of TRPC6 inhibition in Breast cancer stem cell (BCSC) enriched models. The effect of TRPC6 inhibition in Breast cancer stem cell (BCSC) enriched models

We found several genes differentially regulated by TRPC6, and in this study focused on ESRP1 (Epithelial Splicing Regulatory Protein 1) Overall design: To identify downstream signaling pathways regulated by TRPC6 we designed a time-course expereiment treating cells with the TRPC6 inhibitor for 6 and 12 hours and DMSO as control for the respective time-points.