Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7

Production of type I IFN genes in response to Toll-like receptor 3 (TLR3) and TLR4 ligands is mediated by TANK-binding kinase 1 (TBK1) or I-kappa-B kinase epsilon (IKKε, IKBKE), which phosphorylate IFN regulatory factor 3 (IRF3) and IRF7. The activity of TBK1 and/or IRF3, IRF7 is regulated by multiple mechanisms including post-translational modifications, protein-protein interactions, and protein degradation (Zhao W et al., 2013; Runde AP et al., 2022). <p>This Reactome module describes regulation of TBK1, IKKε activity by K63-linked ubiquitination of TBK1 and IKKε, and TBK1 interaction with OPTN. <br>.

对Toll样受体3（TLR3）和TLR4配体的响应下，I型干扰素基因的产生由TANK结合激酶1（TBK1）或I-κB激酶ε（IKKε，即IKBKE）介导，这些激酶通过磷酸化干扰素调节因子3（IRF3）和IRF7发挥作用。TBK1和/或IRF3、IRF7的活性受到多种机制的调控，包括翻译后修饰、蛋白质-蛋白质相互作用和蛋白质降解（Zhao W等人，2013；Runde AP等人，2022）。本Reactome模块描述了TBK1、IKKε活性通过TBK1和IKKε的K63连接泛素化以及TBK1与OPTN相互作用进行调节的情况。