Additional file 1 of Regenerative capacity of trophoblast stem cell-derived extracellular vesicles on mesenchymal stem cells

Additional file 1: Supplemental Methods. Supplementary Figure 1. Flow chart of transcriptomic analysis in this study. Supplementary Figure 2. Characterization of TSC-EV and MSC-EV. Supplementary Figure 3. Increased proliferation rate of human MSCs via TSC-derived CM and EV. Supplementary Figure 4. Significant biological processes and pathway of four microRNAs primed by TSC-EVs. Supplementary Figure 5. DEGs in significant KEGG pathways and enriched GO terms in TSC-EV-treated MSCs. Supplementary Figure 6. Bone regeneration effect of TSC-EVs. Supplementary Figure 7. Anti-senescence and wound-healing effects of TSC-derived secretomes. Supplementary Figure 8. Anti-NGF effect on MSCs and TSC-EV-treated MSCs. Supplementary Table 1. Primer sequences used in qRT-PCR. Supplementary Table 2. List of antibodies and chemical materials used in this study. Supplementary Table 3. Statistics results of microRNA analysis data. Supplementary Excel Table 1. microRNA total read counts in TSC- and MSC-EV. Source Data of Western Blotting.