Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.
收藏Protein Data Bank Japan2024-10-16 更新2026-03-21 收录
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Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor. Descriptor: 2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ... Authors: Mohr, C. Deposit date: 2019-06-08 Release date: 2019-08-28 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. Acs Med.Chem.Lett., 10, 2019
创建时间：
2019-06-08
