Whole Sequencing Of The Mitochondrial Genome Of Breast Tumor Tissue In Mexican-Mestizo Postmenopausal Women, With Different Body Mass Index

Mitochondrial and oxidative stress have been related to obesity and breast cancer, and this cancer is more frequent and more aggressive in postmenopausal women with obesity. To investigate if Mexican-Mestizo postmenopausal women with breast cancer and obesity presented different somatic mutations in the mitochondrial DNA (mtDNA) when compared to women with normal body mass index. The whole mtDNA sequence was determined by MitoChip v2.0 mitochondrial resequencing array, and the analysis of data was performed using the GeneChip Sequence Analysis Software. Mitochondrial tumor DNA sequence was compared with matched leukocyte mtDNA sequence.