Novel Synthesis of Highly Functionalized 14-β-Hydroxysteroids Related to Batrachotoxin and Ouabain
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https://figshare.com/articles/dataset/Novel_Synthesis_of_Highly_Functionalized_14_Hydroxysteroids_Related_to_Batrachotoxin_and_Ouabain/3350971
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资源简介：
The use of anionic polycyclization was investigated in an effort to develop a versatile and convergent
synthesis of advanced tetracyclic intermediates of batrachotoxin and ouabain analogues. Two new
5-(trialkylsilyl)-2-cyclohexenones as A ring precursors and a new Nazarov intermediate (D ring
precursor) were prepared for this purpose. The reaction of the unsaturated β-keto aldehyde A ring
precursor with the enolate of the Nazarov intermediate afforded, after subsequent transformations,
a 14-β-hydroxysteroid with complete control of stereochemistry.
创建时间：
2004-02-06
