Flycodes enable preclinical analysis of dozens of antibodies using single cassette-dosed mice. Dataset 1/6

During discovery and development of protein-based drugs, extensive animal testing is required for preclinical analysis of pharmacokinetics, tissue biodistribution, toxicity, etc. Generally, several animals are required for testing a single drug. We show that the use of genetically encoded peptide barcodes, called flycodes, allows for the simultaneous preclinical assessment of dozens of antibodies from single cassette-dosed mice. Datasets: 1. comparison of flycodes vs. unique endogenous tryptic peptides for antibody identification 2. antibody PK, cassette dose A (high dose) 3. antibody PK, cassette dose B (low dose) 4. antibody tumor/organ biodistribution 5. Dar-SB thermostability 6. Dar-SB PK