Genome wide examination of alterations in mRNA translation in striatal D1 neurons in Fmr1 model mice. Genome wide examination of alterations in mRNA translation in striatal D1 neurons in Fmr1 model mice

We immunoprecipitated GFP tagged ribosomes from Drd1 receptor-expressing cells in the striatum from adult WT and fragile X syndrome model mice and sequenced the co-purifying mRNA (IP). We also sequenced the RNA in the striatal lysate (total). Overall design: Examination of ribosome bound mRNA in D1 neurons from FMRP mutant mice.