Two Novel Pharmaceutical Cocrystals of a Development Compound – Screening, Scale-up, and Characterization
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https://figshare.com/articles/dataset/Two_Novel_Pharmaceutical_Cocrystals_of_a_Development_Compound_Screening_Scale_up_and_Characterization/2542474
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资源简介：
A streamlined methodology for cocrystal screening and
scale-up
has been developed. There are two parts to this procedure: (1) a high
throughput screening approach for the rapid identification of potential
cocrystal leads and (2) a new procedure for solvent selection, rapidly
mapping the critical region in the ternary phase diagram, and determining
a cocrystallization procedure for scale-up. Using this approach, we
have discovered and scaled-up two new cocrystal forms of the pharmaceutically
active compound 1 for the treatment of type II diabetes.
This approach provided more than 2 g of cocrystal material suitable
for biopharmaceutical evaluation. The physicochemical characterization
and single crystal X-ray diffraction data of these cocrystals are
also presented and discussed.
创建时间：
2012-03-07
