Tsc1a knockdown and Mycobacterium marinum infection
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE246264
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We identify a putative link between miR-126 and the tsc1a signalling pathway resulting in the suppression of permissive macrophage accumulation at early zebrafish-M. marinum granulomas. Mechanistically, we find a detrimental effect of tsc1a expression that renders zebrafish embryos susceptible to higher bacterial burden and increased cell death via mTOR inhibition. Whole zebrafish embryo RNAseq of scram and tsc1a gRNA/Cas9-injected, with and without Mycobacterium marinum infection
创建时间:
2023-10-27



