Nitrogen Atom Transfer Enables the (5+1) Annulation Reaction to Access Aminoisoquinolines

Herein,
a catalytic synthetic transformation offering a series
of -NH2 group-bearing aminoisoquinolines with moderate
to good yields has been showcased. Interestingly, the nitrogen atom
of the isoquinoline ring is coming from the reaction medium upon metal-assisted
CN bond cleavage. Moreover, this (5+1) annulation reaction
shows broad substrate variation. Furthermore, the derivatization of
the isoquinoline core via functional group interconversions and mechanistic
studies to identify the reaction intermediate have been carried out
successfully.