t1/2 for degradation were based on exponential decay curve fitting equation (see figure 5 legend for equation).
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The EC50's were also calculated after correcting for Tac expression and fitted in SigmaPlot using a four parameter logistic model (Hill-Slope model) with the equation y = y0+(a/(1+(x/x0)b)) where b = slope, y = concentration, x0 = EC50 and a = maximum response. [26], [27], [28], [38]. The p-values for Tac-TGN38: Tac-furin were 0.03.
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2015-12-02



