Alkali-Induced Ring-Opening of 2‑Amidodihydrofuran and Manganese-Catalyzed Aerobic Dehydrogenation Annulation: Access to Functionalized Oxazole

A novel
and efficient synthesis of functionalized oxazoles from
2-amidodihydrofurans has been achieved by alkali-induced intramolecular
C–O bond cleavage and formation using air as a green oxidant.
Moreover, these functionalized oxazoles could be readily transformed
into the corresponding oxazole-substituted pyrazoles and 2H-azirines.