Novel Alterations in Chromatin Structure during Aging Reveal Cell-Specific Differential Expression of SUMO Proteins

We investigated the chromatin accessibility of primary human adipose-derived stem cells (ASCs) and fibroblasts during chronological aging using ATAC-seq technology. our data suggest a significant role for nucleosome positioning in sumoylation pathway regulation in response to stress during aging of adult stem cells. Overall design: Compared chromatin accessiblity and promoter nucleosome positioning of human ASCs and fibroblasts during aging