Treg fitness signatures as a biomarker for disease activity in Juvenile Idiopathic Arthritis

biomarker discovery pipeline for active and subclinical JIA through 48 gene Treg signature+ nanoString normalised counts from peripheral blood and synovial fluid mononuclear cells and Tregs a cohort of healthy adult control PBMC (n=20) and Tregs (n=26); pediatric healthy control PBMC (n=5) and Tregs (n=5); JIA SFMC (n=29) and SF Tregs (n=26); active (AJC>=1) JIA PBMC (n=30) and Tregs (n=30); and inactive (AJC=0) PBMC (n=17) and Tregs (n=17), assessed for 48-gene nanoString Treg signature+ for biomarker discovery to identify active JIA CHARMS,study JIAP,study