Genome-wide gene expression changes in peripheral granulocytes and monocytes from TB patients

Mycobacterium tuberculosis (Mtb) causes a wide spectrum of human disease ranging from asymptomatic latent infection to severe host pathology, but it remains unclear how Mtb influence on leukocyte gene expression differs between disease states. We assessed mRNA expression in blood monocytes and granulocytes by next-generation sequencing in healthy controls and patients with active tuberculosis infection. We found genome-wide gene expression changes in granulocyte and monocyte which correlated with disease severity. Overall design: We assessed mRNA expression in peripheral blood monocytes and granulocytes in healthy controls and patients with active tuberculosis infection.