The gene expression profiles associated with worsening left ventricle function after mitral valve repair

Background:To assess left ventricular (LV) transcriptome determinants of worsening LV function after mitral valve (MV) repair. Results:Upregulated protein ubiquitination-related genes associated with worsening-LVF after MV repair may likely exert its adverse effect in left ventricle through increased apoptosis and contractile protein degradation. A total of 13 patients were divided into two groups for study: preserved LV function (preserved-LVF, N=8) and worsening LV function (worsening-LVF, N=5) after MV repair for severe, isolated chronic mitral regurgitation. Specimens of left ventricle from the patients were used for gene microarray study.