Visible Light-Promoted Friedel–Crafts-Type Chloroacylation of Alkenes to β‑Chloroketones

The
photoredox chloroacylation of alkenes has been developed as
a substitute for the Friedel–Crafts acylation of alkenes to
β-chloroketones. The direct generation of acyl radical species
from acid chlorides under the photoredox conditions allows the formation
of β-chloroketones without dehydrochlorination with the help
of KHCO3. The synthetic utility of the current method is
demonstrated in the one-pot synthesis of dihydroisoxazole, dihydropyrazole,
and dihydropyrimidine-2-thione in 1 mmol scale.