Therapeutic Effect of Histone Acetyltransferase Inhibitors on Galactose-Induced Cataract in Rats
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE186248
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资源简介：
We investigated the therapeutic effects of histone acetyltransferase (HAT) inhibitors on cataracts using an ex vivo model of galactose-induced cataracts in the rat lens.Among the tested HAT inhibitors, TH1834 was the only inhibitor that could completely reverse white opacities once formed in the lens. Combination treatment with C646/CPTH2 and CBP30/CPTH2 also had therapeutic effects. To identify the genes regulated by HAT inhibitors, we conducted microarray analysis of treated and untreated cataract samples. Genes that increased in galactose-treated lenses and reverted with HAT inhibitors were extracted.
创建时间：
2023-03-12
