PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118

Upon stimulation FAK1 (also known as PTK2), in association with Src family kinases (SFKs) phosphorylates paxillin (PXN) at two main sites- tyrosine 31 and tyrosine 118. These phosphorylated sites provides the functional SH2-binding sites for members of the Crk family of SH2-SH3 adaptor proteins (Bellis et al. 1995, Shaller & Schaefer 2001).

在受到刺激后，FAK1（亦称PTK2）与Src家族激酶（SFKs）相结合，在两个主要位点——酪氨酸31和酪氨酸118上磷酸化paxillin（PXN）。这些磷酸化位点为Crk家族SH2-SH3适配蛋白成员提供了功能性的SH2结合位点（Bellis等，1995；Shaller & Schaefer，2001）。