Multimodal smart systems reprMultimodal smart systems reprogram macrophages and remove urate to treat gouty arthritisogram macrophages and remove urate to treat gouty arthritis

Gouty arthritis (GA) is a chronic and progressive disease that often develops due to high urate levels, leading to joint damage and characterized by an inflammatory immune microenvironment (IIMe). Quantitative proteomics further revealed D-N camouflaged with hybid membranes of M2 exosome and its parent microphage (D-N[EM2]) treated GA disease mechanisms.