File S1 - Real-Time Monitoring of Protein Conformational Changes Using a Nano-Mechanical Sensor

Materials and methods, in depth description of the Topo II cycle, additional control experiments and the theoretical model. Additional figures, mainly regarding the characterization of the cantilever and the additional experiments. (DOCX)材料与方法部分，对Topo II循环进行了深入的描述，并补充了控制实验和理论模型。此外，还增添了若干图表，主要涉及悬臂的表征及额外实验。