Rapid, One-Pot Synthesis of β-Siloxy-α-haloaldehydes
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https://figshare.com/articles/dataset/Rapid_One_Pot_Synthesis_of_Siloxy_haloaldehydes/2614684
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The Mukaiyama cross-aldol reaction of α-fluoro-, α-chloro-, and α-bromoacetaldehyde-derived (Z)-tris(trimethylsilyl)silyl enol ethers is described, furnishing anti-β-siloxy-α-haloaldehydes. A highly diastereoselective, one-pot, sequential double-aldol process is developed, affording novel β,δ-bissiloxy-α,γ-bishaloaldehydes. Reactions are catalyzed by C6F5CHTf2 and C6F5CTf2AlMe2 (0.5–1.5 mol %) and provide access to halogenated polyketide fragments.
创建时间：
2016-02-23
