PARP-1/PARP-2 double deficiency results in recurrent early pregnancy loss and decidualization failure in mice
收藏Alliance of Genome Resources2026-08-01 收录
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Specifically, we found inhibition of PARP-1 and PARP-2 catalytic activity, or tissue-specific genetic knockout, results in a severe fertility defect. Transcriptomic analysis uncovered that PARP-1;PARP-2-deficient mice have defects in the progression of stromal cell decidualization manifesting in pregnancy failure RNAseq libraries were generated from control and knockout implantation sites on gestational days 4, 5, and 6.
