MADCaP_AndrogeneticAlopecia_SummaryStatistics.tsv

MADCaP_AndrogeneticAlopecia_SummaryStatistics.tsv contains the summary statistics for the ordinal GWAS of androgenetic alopecia phenotyped on the 1-4 UK Biobank scale after pooling 2,136 samples from Senegal, Ghana, Nigeria, and South Africa. These summary statistics correspond to the manuscript by Janivara et al: "Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men." This is a product of the MADCaP Network (https://www.madcapnetwork.org).<br><br>Column headers are as follows:<b>chromosome</b>: Chromosome of the SNP<b>base_pair_location</b>: hg38 coordinates of the SNP<b>effect_allele</b>: Allele for which effect size is reported<b>other_allele</b>: Other allele<b>beta</b>: Effect size with direction referenced with the effect allele<b>standard_error</b>: Standard Error of Effect Size Estimate in the MADCaP male pattern baldness GWAS<b>effect_allele_frequenc</b>y: Frequency of the effect allele<b>p_value</b>: P-value of GWAS association<b>variant_ID</b>: SNP ID

MADCaP_AndrogeneticAlopecia_SummaryStatistics.tsv 包含了合并塞内加尔、加纳、尼日利亚及南非共2136例样本后，针对基于1-4级英国生物样本库（UK Biobank）表型分型的雄激素性脱发（androgenetic alopecia）开展的有序全基因组关联研究（Genome-Wide Association Study, GWAS）的汇总统计量。该汇总统计量对应Janivara等人发表的研究论文：《解析非洲男性雄激素性脱发的遗传架构与进化根源》(Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men)。本数据集由MADCaP联盟产出，其官方网址为https://www.madcapnetwork.org。<br><br>列名说明如下：<b>chromosome</b>：单核苷酸多态性（Single Nucleotide Polymorphism, SNP）所在染色体；<b>base_pair_location</b>：SNP的hg38基因组坐标；<b>effect_allele</b>：报告效应量的效应等位基因；<b>other_allele</b>：其他等位基因；<b>beta</b>：以效应等位基因为参照的带方向效应量；<b>standard_error</b>：MADCaP男性型秃发GWAS中效应量估计值的标准误；<b>effect_allele_frequency</b>：效应等位基因频率；<b>p_value</b>：GWAS关联分析的P值；<b>variant_ID</b>：SNP位点ID

搜集汇总

背景与挑战

背景概述

该数据集是雄性激素性脱发（男性型秃发）的GWAS汇总统计文件，基于2,136个非洲男性样本（来自塞内加尔、加纳、尼日利亚和南非）的UK Biobank表型数据，用于研究该疾病的遗传结构和进化根源。数据集包含染色体位置、等位基因、效应大小、p值等标准统计列，支持开放获取（CC BY 4.0许可证），适用于基因组学和进化遗传学分析。